|
FH535
|
PPARgamma, PPARdelta
|
WNT signaling
|
3463933
|
40
|
-5,225
|
361,204
|
2,593
|
0
|
|
GSK269962A
|
ROCK1, ROCK2
|
Cytoskeleton
|
16095342
|
8
|
-5,223
|
570,608
|
3,0598
|
2
|
|
FR-180204
|
ERK1, ERK2
|
ERK MAPK signaling
|
11493598
|
70
|
-5,218
|
327,35
|
1,1184
|
0
|
|
AZD7762
|
CHEK1, CHEK2
|
Cell cycle
|
11152667
|
80
|
-5,206
|
362,428
|
2,2935
|
0
|
|
EHT-1864
|
RAC1, RAC2, RAC3
|
Cytoskeleton
|
9938202
|
94
|
-5,172
|
508,559
|
4,0947
|
1
|
|
JNK-9L
|
JNK2, JNK3
|
JNK and p38 signaling
|
25222038
|
38
|
-5,142
|
502,552
|
2,5999
|
1
|
|
SNX-2112
|
HSP90
|
Protein stability and degradation
|
24772860
|
50
|
-5,111
|
464,486
|
2,4294
|
0
|
|
PD0325901
|
MEK1, MEK2
|
ERK MAPK signaling
|
9826528
|
100
|
-5,108
|
482,191
|
2,0157
|
0
|
|
CUDC-101
|
HDAC1-10, EGFR, ERBB2
|
Other
|
24756910
|
51
|
-5,085
|
434,494
|
4,1439
|
0
|
|
Bicalutamide
|
AR
|
Hormone-related
|
2375
|
14
|
-5,084
|
430,377
|
2,1426
|
0
|
|
GSK429286A
|
ROCK1, ROCK2
|
Cytoskeleton
|
11373846
|
74
|
-5,084
|
432,376
|
3,3102
|
0
|
|
Gefitinib
|
EGFR
|
EGFR signaling
|
123631
|
115
|
-5,062
|
446,909
|
3,9851
|
0
|
|
BX-912
|
PDK1 (PDPK1)
|
PI3K/MTOR signaling
|
11754511
|
60
|
-4,999
|
471,362
|
3,2725
|
0
|
|
Pyrimethamine
|
Dihydrofolate reductase (DHFR)
|
Other
|
4993
|
150
|
-4,909
|
248,716
|
2,5414
|
0
|
|
Axitinib
|
PDGFR, KIT, VEGFR
|
RTK signaling
|
6450551
|
110
|
-4,87
|
386,478
|
3,4441
|
0
|
|
MG-132
|
Proteasome, CAPN1
|
Protein stability and degradation
|
462382
|
128
|
-4,865
|
475,628
|
3,1698
|
0
|
|
Masitinib
|
KIT, PDGFRA, PDGFRB
|
Other, kinases
|
10074640
|
90
|
-4,849
|
498,653
|
4,7573
|
0
|
|
CGP-60474
|
CDK1,CDK2,CDK5,CDK7,CDK9, PKC
|
Cell cycle
|
644215
|
124
|
-4,828
|
355,828
|
3,284
|
0
|
|
KIN001-260
|
IKKB
|
Other
|
10451420
|
83
|
-4,726
|
364,448
|
1,4664
|
0
|
|
Dasatinib
|
ABL, SRC, Ephrins, PDGFR, KIT
|
Other
|
3062316
|
121
|
-4,701
|
488,014
|
3,6259
|
0
|
