|
SB216763
|
GSK3A, GSK3B
|
WNT signaling
|
176158
|
136
|
-4,165
|
371,222
|
2,8893
|
0
|
|
Cetuximab
|
EGFR
|
EGFR signaling
|
85668777
|
15
|
-4,16
|
273,375
|
3,5719
|
0
|
|
LFM-A13
|
BTK
|
Other, kinases
|
54676905
|
21
|
-4,141
|
360,005
|
3,1556
|
0
|
|
Obatoclax Mesylate
|
BCL2, BCL-XL, BCL-W, MCL1
|
Apoptosis regulation
|
11404337
|
73
|
-4,042
|
317,391
|
2,441
|
0
|
|
Etoposide
|
TOP2
|
DNA replication
|
36462
|
146
|
-3,952
|
588,56
|
0,6726
|
2
|
|
Ruxolitinib
|
JAK1, JAK2
|
Other, kinases
|
25126798
|
41
|
-3,921
|
306,372
|
1,6767
|
0
|
|
Pevonedistat
|
NAE
|
Other
|
16720766
|
56
|
-3,89
|
443,527
|
2,0249
|
0
|
|
SL0101
|
RSK, AURKB, PIM1, PIM3
|
Other
|
10459196
|
82
|
-3,814
|
516,454
|
1,8947
|
2
|
|
Methotrexate
|
Antimetabolite
|
DNA replication
|
126941
|
139
|
-3,767
|
454,446
|
-1,2285
|
1
|
|
AT-7519
|
CDK1, CDK2, CDK4, CDK6, CDK9
|
Cell cycle
|
11338033
|
76
|
-3,751
|
382,25
|
1,6537
|
0
|
|
AZD6482
|
PI3Kbeta
|
PI3K/MTOR signaling
|
44137675
|
4
|
-3,738
|
408,457
|
1,1581
|
0
|
|
CCT-018159
|
HSP90
|
Protein stability and degradation
|
5327091
|
116
|
-3,732
|
352,389
|
1,4486
|
0
|
|
Daporinad
|
NAMPT
|
Metabolism
|
6914657
|
106
|
-3,697
|
391,513
|
3,9862
|
0
|
|
Embelin
|
XIAP
|
Apoptosis regulation
|
3218
|
153
|
-3,684
|
294,389
|
4,069
|
0
|
|
AS601245
|
JNK1, JNK2, JNK2
|
JNK and p38 signaling
|
10109823
|
88
|
-3,671
|
372,455
|
2,5541
|
0
|
|
Belinostat
|
HDAC1
|
Chromatin histone acetylation
|
6918638
|
105
|
-3,607
|
318,352
|
1,2586
|
0
|
|
BIX02189
|
MEK5, ERK5
|
ERK MAPK signaling
|
46931012
|
27
|
-3,558
|
440,545
|
2,5512
|
0
|
|
Dacinostat
|
HDAC1
|
Chromatin histone acetylation
|
6445533
|
112
|
-3,541
|
379,459
|
1,9496
|
0
|
|
Erlotinib
|
EGFR
|
EGFR signaling
|
176870
|
134
|
-3,527
|
393,442
|
3,0713
|
0
|
|
SB52334
|
ALK5
|
RTK signaling
|
9967941
|
92
|
-3,502
|
343,433
|
3,7172
|
0
|
