|
OSU-03012
|
PDK1 (PDPK1)
|
Other, kinases
|
10027278
|
91
|
-7,054
|
460,458
|
4,2489
|
0
|
|
PD173074
|
FGFR1, FGFR3
|
RTK signaling
|
1401
|
154
|
-7,012
|
523,68
|
4,5825
|
1
|
|
Dabrafenib
|
BRAF
|
ERK MAPK signaling
|
44462760
|
32
|
-7,001
|
519,571
|
4,5416
|
1
|
|
Cabozantinib
|
VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, TIE2,AXL
|
Other, kinases
|
25102847
|
43
|
-6,978
|
501,513
|
4,0714
|
1
|
|
SGC0946
|
DOT1L
|
Chromatin histone methylation
|
56962337
|
19
|
-6,964
|
618,575
|
3,3752
|
2
|
|
Omipalisib
|
PI3K (class 1), MTORC1, MTORC2
|
PI3K/MTOR signaling
|
25167777
|
40
|
-6,957
|
505,504
|
3,2454
|
1
|
|
Linsitinib
|
IGF1R
|
IGFR signaling
|
11640390
|
64
|
-6,927
|
421,503
|
4,0356
|
0
|
|
CP724714
|
ERBB2
|
EGFR signaling
|
9874913
|
97
|
-6,726
|
469,543
|
4,1071
|
0
|
|
CI-1040
|
MEK1, MEK2
|
ERK MAPK signaling
|
6918454
|
100
|
-6,682
|
478,659
|
4,3331
|
0
|
|
Refametinib
|
MEK1, MEK2
|
ERK MAPK signaling
|
44182295
|
3
|
-6,587
|
572,337
|
3,0278
|
1
|
|
AZ628
|
BRAF
|
ERK MAPK signaling
|
11676786
|
62
|
-6,584
|
451,529
|
4,6632
|
0
|
|
Doramapimod
|
p38, JNK2
|
JNK and p38 signaling
|
156422
|
137
|
-6,546
|
527,667
|
5,0942
|
2
|
|
681640
|
WEE1, CHEK1
|
Cell cycle
|
10384072
|
84
|
-6,539
|
362,771
|
4,0165
|
0
|
|
NG-25
|
TAK1, MAP4K2
|
Other, kinases
|
53340664
|
22
|
-6,505
|
537,584
|
4,8239
|
1
|
|
PF-562271
|
FAK, FAK2
|
Cytoskeleton
|
11713159
|
61
|
-6,465
|
507,496
|
1,6748
|
1
|
|
BX796
|
TBK1, PDK1 (PDPK1), IKK, AURKB, AURKC
|
Other
|
10077147
|
60
|
-6,424
|
591,472
|
4,1768
|
1
|
|
Bexarotene
|
Retinioic X receptor (RXR) agonist
|
Other
|
82146
|
142
|
-6,389
|
348,484
|
4,799
|
0
|
|
Lestauritinib
|
FLT3, JAK2, NTRK1, NTRK2, NTRK3
|
Other, kinases
|
126565
|
140
|
-6,38
|
439,47
|
3,9394
|
0
|
|
HG6-64-1
|
BRAF
|
ERK MAPK signaling
|
53302361
|
22
|
-6,362
|
577,649
|
5,5653
|
2
|
|
KIN001-266
|
MAP3K8
|
Other, kinases
|
44143370
|
35
|
-6,351
|
539,445
|
4,6769
|
1
|
