• Anticancer drugs
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Genomics of Drug Sensitivity in Cancer
Targets
Target pathway
Download molecule
Cluster number
calculated LogS
Molecular weight
calculated LogP
Ro5 violations
GSK1904529A IGF1R, IR IGFR signaling 25124816 42 -10,163 851,977 6,3969 3
Dactolisib PI3K (Class 1), MTORC1, MTORC2 PI3K/MTOR signaling 11977753 59 -9,336 469,547 6,2031 1
JW-7-52-1 MTOR PI3K/MTOR signaling 49836027 24 -8,841 607,634 6,5509 2
Navitoclax BCL2, BCL-XL, BCL-W Apoptosis regulation 24978538 45 -8,804 974,628 9,0239 3
Nilotinib ABL ABL signaling 644241 53 -8,55 529,525 5,1058 2
GSK319347A IKK Other 11626927 65 -8,395 469,541 2,985 0
GW843682X PLK1 Cell cycle 9826308 65 -8,072 477,462 4,083 0
Lapatinib ERBB2, EGFR EGFR signaling 208908 133 -8,061 581,066 4,7281 1
JQ1 BRD2, BRD3, BRD4, BRDT Chromatin other 46907787 1 -8,027 456,997 5,1115 1
NU7441 DNAPK Genome integrity 11327430 77 -8,01 413,496 5,3412 1
GSK650394 SGK2, SGK3 Other 25022668 44 -7,873 382,462 5,5793 1
NVP-BHG712 EPHB4 Other 16747388 53 -7,812 503,487 4,6221 1
KIN001-270 CDK9 Cell cycle 66577006 17 -7,778 499,55 3,9502 0
AKT inhibitor VIII AKT1, AKT2, AKT3 PI3K/MTOR signaling 10196499 10 -7,617 551,652 5,3664 2
MPS-1-IN-1 MPS1 Mitosis 25195352 39 -7,328 535,667 4,2095 1
CHIR-99021 GSK3A, GSK3B WNT signaling 9956119 12 -7,316 465,347 3,6043 0
PLX-4720 BRAF ERK MAPK signaling 24180719 5 -7,244 413,831 2,9187 0
MK-2206 AKT1, AKT2 PI3K/MTOR signaling 46930998 28 -7,24 407,476 3,8716 0
PHA-665752 MET RTK signaling 10461815 81 -7,115 641,618 4,3877 1
Linifanib VEGFR1, VEGFR2, VEGFR3, CSF1R, FLT3, KIT RTK signaling 11485656 71 -7,063 375,406 3,7895 0
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