| Molecule Name |
PE000189
|
| Refractivity |
289
|
| SMILES format |
[H][C@]1([C@@H](O)[C@H](OC2=CC(O)=CC(O)=C12)C1=CC(O)=C(O)C=C1)C1=C2O[C@]3(OC4=C(C5=C(C(O)=C4)[C@@]([H])([C@@H](O)[C@H](O5)C4=CC(O)=C(O)C=C4)C4=C(O)C=C(O)C5=C4O[C@@H]([C@H](O)C5)C4=CC(O)=C(O)C=C4)[C@]([H])([C@H]3O)C2=C(O)C=C1O)C1=CC(O)=C(O)C=C1
|
| Resonant Structures |
1
|
| TPSA |
431
|
| ASA hydrophobic |
548
|
| ASA polar |
510
|
| Accessible Surface Area |
1058
|
| LogS |
-6
|
| MW |
1153
|
| cLogP |
4
|
| H-Acceptors |
24
|
| H-Donors |
19
|
| Ro5 violations |
3
|
| DrugScore |
0
|
| Druglikeness |
1
|
| Irritant |
none
|
| Mutagenic |
none
|
| Reproductive Effective |
high
|
| Tumorigenic |
none
|
| Fish Toxicity |
High FHMT
|
| Fish Toxicity 2 |
1.3941
|
| Rat Acute Toxicity |
2
|
| Acute Oral Toxicity |
IV
|
| Caco-2 Permeability |
Caco2-
|
| Caco-2 Permeability 2 |
-1
|
| P-glycoprotein Substrate |
Substrate
|
| P-glycoprotein Inhibitor |
Non-inhibitor
|
| P-glycoprotein Inhibitor 2 |
Non-inhibitor
|
| Human Ether-a-go-go-Related Gene Inhibition |
Weak inhibitor
|
| Human Ether-a-go-go-Related Gene Inhibition 2 |
Non-inhibitor
|
| CYP450 2C9 Substrate |
Non-substrate
|
| Tetrahymena Pyriformis Toxicity |
High TPT
|
| Tetrahymena Pyriformis Toxicity 2 |
1
|
| AMES Toxicity |
Non AMES toxic
|
| CYP450 3A4 Inhibitor |
Non-inhibitor
|
| CYP450 3A4 Substrate |
Non-substrate
|
| CYP450 2C19 Inhibitor |
Non-inhibitor
|
| CYP450 2C9 Inhibitor |
Non-inhibitor
|
| CYP450 2D6 Inhibitor |
Non-inhibitor
|
| CYP450 1A2 Inhibitor |
Non-inhibitor
|
| CYP450 2D6 Substrate |
Non-substrate
|
| Biodegradation |
Not ready biodegradable
|
| Carcinogens |
Non-carcinogens
|
| Blood-Brain Barrier |
BBB-
|
| CYP Inhibitory Promiscuity |
Low CYP Inhibitory Promiscuity
|
| Honey Bee Toxicity |
High HBT
|
| Renal Organic Cation Transporter |
Non-inhibitor
|
| Carcinogenicity (Three-class) |
Non-required
|
| Human Intestinal Absorption |
HIA+
|
