| PUBCHEM ID |
90478641
|
| UNII |
21YB614QLY
|
| Preferred Term |
TELOMYCIN
|
| CAS |
19246-24-3
|
| INCHIKEY |
|
| Download |
mol2, pdbqt
|
| mol2 |
|
| Smiles |
CC(C)[C@@H]([C@@H](C(N(CC[C@H]1O)[C@@H]1C(O[C@H](C)[C@@H](C(N[C@@H]([C@H](C)O)C(N[C@@H](C)C(NCC(N(CC[C@@H]1O)[C@@H]1C(N/C(/C(N[C@H]1[C@@H](C)c2c[nH]c3c2cccc3)=O)=C\c2c[nH]c3c2cccc3)=O)=O)=O)=O)=O)NC([C@H](CO)NC(C[C@@H](C(O)=O)N)=O)=O)=O)=O)NC1=O)O
|
| Total Surface Area |
917,35
|
| Relative PSA |
0,42199
|
| TPSA |
495,77
|
| cLogS |
-4,643
|
| MW |
1272,33
|
| cLogP |
-7,2639
|
| H-Acceptors |
32
|
| H-Donors |
17
|
| Ro5 violations |
3
|
| Druglikeness |
-8,2285
|
| DrugScore |
0,198610509428734
|
| Mutagenic |
none
|
| Tumorigenic |
none
|
| Reproductive Effective |
none
|
| Irritant |
none
|
| Blood-Brain Barrier |
BBB-
|
| Human Intestinal Absorption |
HIA+
|
| Caco-2 Permeability I |
Caco2-
|
| Caco-2 Permeability II |
-0,16
|
| P-glycoprotein Substrate |
Substrate
|
| P-glycoprotein Inhibitor I |
Non-inhibitor
|
| P-glycoprotein Inhibitor II |
Non-inhibitor
|
| Renal Organic Cation Transporter |
Non-inhibitor
|
| Subcellular localization |
Mitochondria
|
| CYP450 2C9 Substrate |
Non-substrate
|
| CYP450 2D6 Substrate |
Non-substrate
|
| CYP450 3A4 Substrate |
Substrate
|
| CYP450 1A2 Inhibitor |
Non-inhibitor
|
| CYP450 2C9 Inhibitor |
Non-inhibitor
|
| CYP450 2D6 Inhibitor |
Non-inhibitor
|
| CYP450 2C19 Inhibitor |
Non-inhibitor
|
| CYP450 3A4 Inhibitor |
Non-inhibitor
|
| CYP Inhibitory Promiscuity |
Low CYP Inhibitory Promiscuity
|
| Human Ether-a-go-go-Related Gene Inhibition I |
Weak inhibitor
|
| Human Ether-a-go-go-Related Gene Inhibition II |
Inhibitor
|
| AMES Toxicity |
Non AMES toxic
|
| Carcinogens |
Non-carcinogens
|
| Fish Toxicity I |
High FHMT
|
| Fish Toxicity II |
1,2832
|
| Tetrahymena Pyriformis Toxicity I |
High TPT
|
| Tetrahymena Pyriformis Toxicity II |
0,412
|
| Tetrahymena Pyriformis Toxicity |
Low HBT
|
| Biodegradation |
Not ready biodegradable
|
| Acute Oral Toxicity |
III
|
| Rat Acute Toxicity |
2,8442
|
| Carcinogenicity (Three-class) |
Non-required
|
