SWISS-MODEL Homology Modelling Report

Model Building Report

This document lists the results for the homology modelling project "U7TJA5-MurA-E-faecium" submitted to SWISS-MODEL workspace on Oct. 15, 2017, 7:19 p.m..The submitted primary amino acid sequence is given in Table T1.

If you use any results in your research, please cite the relevant publications:

Marco Biasini; Stefan Bienert; Andrew Waterhouse; Konstantin Arnold; Gabriel Studer; Tobias Schmidt; Florian Kiefer; Tiziano Gallo Cassarino; Martino Bertoni; Lorenza Bordoli; Torsten Schwede. (2014). SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information. Nucleic Acids Research (1 July 2014) 42 (W1): W252-W258; doi: 10.1093/nar/gku340.
Arnold, K., Bordoli, L., Kopp, J. and Schwede, T. (2006) The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. Bioinformatics, 22, 195-201.
Benkert, P., Biasini, M. and Schwede, T. (2011) Toward the estimation of the absolute quality of individual protein structure models. Bioinformatics, 27, 343-350

Results

The SWISS-MODEL template library (SMTL version 2017-09-21, PDB release 2017-09-15) was searched with Blast (Altschul et al., 1997) and HHBlits (Remmert, et al., 2011) for evolutionary related structures matching the target sequence in Table T1. For details on the template search, see Materials and Methods. Overall 249 templates were found (Table T2).

Models

The following models were built (see Materials and Methods "Model Building"):

Model #01

FileBuilt withOligo-StateLigandsGMQEQMEAN
PDB ProMod3 Version 1.0.2. MONOMER
1 x FLC: CITRATE ANION;
0.82-0.15
QMEAN-0.15
-0.24
All Atom0.34
Solvation0.41
Torsion-0.21
TemplateSeq IdentityOligo-stateFound byMethodResolutionSeq SimilarityRangeCoverageDescription
3zh4.1.A66.35monomerBLASTX-ray1.80Å0.48 1 - 418 0.99UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE
LigandAdded to ModelDescription
FLC
CITRATE ANION
PEG✕ - Not biologically relevant.
DI(HYDROXYETHYL)ETHER

Target    MKKIVIKGNRPLAGEVTISGAKNSAVALIPAAILADSPVILEGVPDIQDVHSLIEILEIMGATVHFSNNILEIDPREIVS
3zh4.1.A MRKIVINGGLPLQGEITISGAKNSVVALIPAIILADDVVTLDCVPDISDVASLVEIMELMGATVKRYDDVLEIDPRGVQN

Target IPMPHGKINSLRASYYFMGTLLGKFGEAVVGLPGGCYLGPRPIDLHVKGFEALGAEVTNEHGAMYLRTENKGLRGNRIFM
3zh4.1.A IPMPYGKINSLRASYYFYGSLLGRFGEATVGLPGGCDLGPRPIDLHLKAFEAMGATASYEGDNMKLSAKDTGLHGASIYM

Target DVVSVGATINVMLAAVKAKGQTVIENAAREPEIIDVATLLNNIGAKVRGAGTDVIRIEGVETLHGCRHFMIPDRIEAGTY
3zh4.1.A DTVSVGATINTMIAAVKANGRTIIENAAREPEIIDVATLLNNMGAHIRGAGTNIIIIDGVERLHGTRHQVIPDRIEAGTY

Target LALAAAVGNGIKVKNVIFEHLESFIAKLQEIGVHMKISEDEIEVYPSKELKPANIMTYPYPGFATDLQQPLTALLLMTTG
3zh4.1.A ISLAAAVGKGIRINNVLYEHLEGFIAKLEEMGVRMTVSEDSIFVEEQSNLKAINIKTAPYPGFATDLQQPLTPLLLRANG

Target TSEIIDTIYAKRVNHVPELARMGADITVEGNMIIVNGPNKLHGTEVVASDLRAGACLVIAGLLAEGTTTIYNVDYILRGY
3zh4.1.A RGTIVDTIYEKRVNHVFELAKMDADISTTNGHILYTGGRDLRGTSVKATDLRAGAALVIAGLMAEGKTEITNIEFILRGY

Target DHIIEKLTALGASIEMIEEVGAE
3zh4.1.A SDIIEKLRNLGADIRLVED----




Model #02

FileBuilt withOligo-StateLigandsGMQEQMEAN
PDB ProMod3 Version 1.0.2. MONOMER
None
0.33-4.48
QMEAN-4.48
-4.24
All Atom-3.12
Solvation-2.21
Torsion-3.24
TemplateSeq IdentityOligo-stateFound byMethodResolutionSeq SimilarityRangeCoverageDescription
1rf4.1.A26.96monomerBLASTX-ray2.20Å0.35 178 - 418 0.545-enolpyruvylshikimate-3-phosphate synthase
LigandAdded to ModelDescription
SPQ✕ - Binding site not conserved.
(3R,4S,5R)-5-{[(1R)-1-CARBOXY-2-FLUORO-1-(PHOSPHONOOXY)ETHYL]OXY}-4-HYDROXY-3-(PHOSPHONOOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC ACID

Target    MKKIVIKGNRPLAGEVTISGAKNSAVALIPAAILADSPVILEGVPDIQDVHSLIEILEIMGATVHFSNNILEIDPREIVS
1rf4.1.A --------------------------------------------------------------------------------

Target IPMPHGKINSLRASYYFMGTLLGKFGEAVVGLPGGCYLGPRPIDLHVKGFEALGAEVTNEHGAMYLRTENKGLRGNRIFM
1rf4.1.A --------------------------------------------------------------------------------

Target DVVSVGATINVMLAAVKAKGQTVIENAAREPEIIDVATLLNNIGAKVRGAGTDVIRIEGVETLHGCRHFMIPDRI----E
1rf4.1.A -----------------AEGETKVYDILRGEDVLSTMQVFRDLGVEIEDK-DGVITVQGV----GMAGLKAPQNALNMGN

Target AGTYLALAAAVGNGIKVKNVIF-------EHLESFIAKLQEIGVHMKISEDEIEVYP-----SKELKPANIMTYPYPGFA
1rf4.1.A SGTSIRLISGVLAGADFEVEMFGDDSLSKRPMDRVTLPLKKMGVSIS-GQTERDLPPLRLKGTKNLRPIH---YELPIAS

Target TDLQQPLTALLLMTTGTSEIIDTIYAKRVNHVPE-LARMGADITVEGNMIIVNGPNKLHGTEVVA-SDLRAGACLVIAGL
1rf4.1.A AQVKSALMFAALQAKGESVIIEKEYTR--NHTEDMLQQFGGHLSVDGKKITVQGPQKLTGQKVVVPGDISSAAFWLVAGL

Target LAEGTTTIYNVDYILRGYDHIIEKLTALGASIEMIEEVGAE
1rf4.1.A IAPNSRLVLQNVGINETRTGIIDVIRAMGGKLEITE-----




Materials and Methods

Template Search

Template search with Blast and HHBlits has been performed against the SWISS-MODEL template library (SMTL, last update: 2017-09-21, last included PDB release: 2017-09-15).

The target sequence was searched with BLAST (Altschul et al., 1997) against the primary amino acid sequence contained in the SMTL. A total of 67 templates were found.

An initial HHblits profile has been built using the procedure outlined in (Remmert, et al., 2011), followed by 1 iteration of HHblits against NR20. The obtained profile has then be searched against all profiles of the SMTL. A total of 182 templates were found.

Template Selection

For each identified template, the template's quality has been predicted from features of the target-template alignment. The templates with the highest quality have then been selected for model building.

Model Building

Models are built based on the target-template alignment using ProMod3. Coordinates which are conserved between the target and the template are copied from the template to the model. Insertions and deletions are remodelled using a fragment library. Side chains are then rebuilt. Finally, the geometry of the resulting model is regularized by using a force field. In case loop modelling with ProMod3 fails, an alternative model is built with PROMOD-II (Guex, et al., 1997).

Model Quality Estimation

The global and per-residue model quality has been assessed using the QMEAN scoring function (Benkert, et al., 2011) . For improved performance, weights of the individual QMEAN terms have been trained specifically for SWISS-MODEL.

Ligand Modelling

Ligands present in the template structure are transferred by homology to the model when the following criteria are met (Gallo -Casserino, to be published): (a) The ligands are annotated as biologically relevant in the template library, (b) the ligand is in contact with the model, (c) the ligand is not clashing with the protein, (d) the residues in contact with the ligand are conserved between the target and the template. If any of these four criteria is not satisfied, a certain ligand will not be included in the model. The model summary includes information on why and which ligand has not been included.

Oligomeric State Conservation

Homo-oligomeric structure of the target protein is predicted based on the analysis of pairwise interfaces of the identified template structures. For each relevant interface between polypeptide chains (interfaces with more than 10 residue-residue interactions), the QscoreOligomer (Mariani et al., 2011) is predicted from features such as similarity to target and frequency of observing this interface in the identified templates (Kiefer, Bertoni, Biasini, to be published). The prediction is performed with a random forest regressor using these features as input parameters to predict the probability of conservation for each interface. The QscoreOligomer of the whole complex is then calculated as the weight-averaged QscoreOligomer of the interfaces. The oligomeric state of the target is predicted to be the same as in the template when QscoreOligomer is predicted to be higher or equal to 0.5.

References

Altschul, S.F., Madden, T.L., Schaffer, A.A., Zhang, J., Zhang, Z., Miller, W. and Lipman, D.J. (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res, 25, 3389-3402.
Remmert, M., Biegert, A., Hauser, A. and Soding, J. (2012) HHblits: lightning-fast iterative protein sequence searching by HMM-HMM alignment. Nat Methods, 9, 173-175.
Guex, N. and Peitsch, M.C. (1997) SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis, 18, 2714-2723.
Sali, A. and Blundell, T.L. (1993) Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol, 234, 779-815.
Benkert, P., Biasini, M. and Schwede, T. (2011) Toward the estimation of the absolute quality of individual protein structure models. Bioinformatics, 27, 343-350.
Mariani, V., Kiefer, F., Schmidt, T., Haas, J. and Schwede, T. (2011) Assessment of template based protein structure predictions in CASP9. Proteins, 79 Suppl 10, 37-58.

Table T1:

Primary amino acid sequence for which templates were searched and models were built.

MKKIVIKGNRPLAGEVTISGAKNSAVALIPAAILADSPVILEGVPDIQDVHSLIEILEIMGATVHFSNNILEIDPREIVSIPMPHGKINSLRASYYFMGT
LLGKFGEAVVGLPGGCYLGPRPIDLHVKGFEALGAEVTNEHGAMYLRTENKGLRGNRIFMDVVSVGATINVMLAAVKAKGQTVIENAAREPEIIDVATLL
NNIGAKVRGAGTDVIRIEGVETLHGCRHFMIPDRIEAGTYLALAAAVGNGIKVKNVIFEHLESFIAKLQEIGVHMKISEDEIEVYPSKELKPANIMTYPY
PGFATDLQQPLTALLLMTTGTSEIIDTIYAKRVNHVPELARMGADITVEGNMIIVNGPNKLHGTEVVASDLRAGACLVIAGLLAEGTTTIYNVDYILRGY
DHIIEKLTALGASIEMIEEVGAE

Table T2:

TemplateSeq IdentityOligo-stateFound byMethodResolutionSeq SimilarityCoverageDescription
3zh4.1.A66.35monomerBLASTX-ray1.80Å0.480.99UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE
3zh3.1.A66.11monomerBLASTX-ray2.90Å0.480.99UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE
3zh4.1.A66.51monomerHHblitsX-ray1.80Å0.480.99UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE
3zh3.1.A66.27monomerHHblitsX-ray2.90Å0.480.99UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE
3sg1.1.A48.43monomerBLASTX-ray2.60Å0.430.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1
3sg1.1.A47.24monomerHHblitsX-ray2.60Å0.420.99UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1
3r38.1.A44.60homo-dimerBLASTX-ray2.23Å0.420.99UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1
4r7u.1.A47.36homo-tetramerBLASTX-ray2.45Å0.420.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3r38.1.A44.71homo-dimerHHblitsX-ray2.23Å0.420.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1
5bq2.1.A45.56homo-tetramerBLASTX-ray1.70Å0.420.99UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4r7u.1.A46.63homo-tetramerHHblitsX-ray2.45Å0.420.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3vcy.1.A48.55monomerBLASTX-ray1.93Å0.420.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
5bq2.1.A45.56homo-tetramerHHblitsX-ray1.70Å0.420.99UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3vcy.1.A47.36monomerHHblitsX-ray1.93Å0.420.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
1uae.1.A45.78homo-trimerBLASTX-ray1.80Å0.420.98UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYL TRANSFERASE
3kr6.1.A45.54monomerBLASTX-ray1.70Å0.420.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3swd.1.A45.54monomerBLASTX-ray2.50Å0.420.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
2z2c.1.A45.54homo-tetramerBLASTX-ray2.05Å0.420.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
1uae.1.A45.19homo-trimerHHblitsX-ray1.80Å0.410.98UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYL TRANSFERASE
1naw.1.A45.78homo-tetramerBLASTX-ray2.00Å0.420.98UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYL-TRANSFERASE
1naw.1.B45.78homo-tetramerBLASTX-ray2.00Å0.420.98UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYL-TRANSFERASE
3spb.1.A45.54homo-tetramerBLASTX-ray2.30Å0.420.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
1eyn.1.A45.54monomerBLASTX-ray1.70Å0.420.98UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE
1ejc.1.A45.54monomerBLASTX-ray1.80Å0.420.98UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYLTRANSFERASE
3su9.1.A45.54monomerBLASTX-ray2.20Å0.420.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
1ybg.1.A45.54homo-tetramerBLASTX-ray2.60Å0.420.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3spb.1.B45.54homo-tetramerBLASTX-ray2.30Å0.420.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3kqa.1.A45.54monomerBLASTX-ray2.25Å0.420.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3kqa.4.A45.54monomerBLASTX-ray2.25Å0.420.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3lth.1.A45.54monomerBLASTX-ray1.75Å0.420.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
1ejd.3.B45.54homo-tetramerBLASTX-ray1.55Å0.420.98UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYLTRANSFERASE
4e7d.1.A45.54monomerBLASTX-ray2.50Å0.420.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4e7d.4.A45.54monomerBLASTX-ray2.50Å0.420.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4e7b.3.A45.54monomerBLASTX-ray2.00Å0.420.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4e7b.2.A45.54monomerBLASTX-ray2.00Å0.420.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4e7d.3.A45.54monomerBLASTX-ray2.50Å0.420.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4e7b.4.A45.54monomerBLASTX-ray2.00Å0.420.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3kr6.1.A44.95monomerHHblitsX-ray1.70Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3swd.1.A44.95monomerHHblitsX-ray2.50Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
2z2c.1.A44.95homo-tetramerHHblitsX-ray2.05Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
1a2n.1.A45.54homo-trimerBLASTX-ray2.80Å0.410.98UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYL TRANSFERASE
4eii.1.A45.30monomerBLASTX-ray1.95Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3swa.1.A45.30monomerBLASTX-ray1.90Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
1a2n.1.A44.95homo-trimerHHblitsX-ray2.80Å0.410.98UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYL TRANSFERASE
1q3g.1.A45.30homo-tetramerBLASTX-ray2.65Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
5wi5.1.A43.61monomerBLASTX-ray2.00Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1
1ryw.1.A45.30homo-tetramerBLASTX-ray2.30Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
1dlg.3.C45.30homo-tetramerBLASTX-ray1.90Å0.410.98UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYL TRANSFERASE MURA
1dlg.3.B45.30homo-tetramerBLASTX-ray1.90Å0.410.98UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYL TRANSFERASE MURA
2rl2.1.A44.12homo-dimerHHblitsX-ray2.30Å0.410.99UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3v4t.1.A45.30homo-tetramerBLASTX-ray2.50Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3v5v.1.A45.30homo-tetramerBLASTX-ray2.70Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3v5v.1.D45.30homo-tetramerBLASTX-ray2.70Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4e7f.1.A45.30monomerBLASTX-ray2.15Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4e7f.2.A45.30monomerBLASTX-ray2.15Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4e7e.2.A45.30monomerBLASTX-ray2.30Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
1naw.1.A44.95homo-tetramerHHblitsX-ray2.00Å0.410.98UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYL-TRANSFERASE
1naw.1.B44.95homo-tetramerHHblitsX-ray2.00Å0.410.98UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYL-TRANSFERASE
3swa.1.A44.71monomerHHblitsX-ray1.90Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
1q3g.1.A44.71homo-tetramerHHblitsX-ray2.65Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3spb.1.A45.06homo-tetramerHHblitsX-ray2.30Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
1eyn.1.A45.06monomerHHblitsX-ray1.70Å0.410.98UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE
1ejc.1.A45.06monomerHHblitsX-ray1.80Å0.410.98UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYLTRANSFERASE
3su9.1.A45.06monomerHHblitsX-ray2.20Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
1ybg.1.A45.06homo-tetramerHHblitsX-ray2.60Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3spb.1.B45.06homo-tetramerHHblitsX-ray2.30Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3kqa.1.A45.06monomerHHblitsX-ray2.25Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3kqa.4.A45.06monomerHHblitsX-ray2.25Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3lth.1.A45.06monomerHHblitsX-ray1.75Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
1ejd.3.B45.06homo-tetramerHHblitsX-ray1.55Å0.410.98UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYLTRANSFERASE
4e7d.1.A45.06monomerHHblitsX-ray2.50Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4e7d.4.A45.06monomerHHblitsX-ray2.50Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4e7b.3.A45.06monomerHHblitsX-ray2.00Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4e7b.2.A45.06monomerHHblitsX-ray2.00Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4e7d.3.A45.06monomerHHblitsX-ray2.50Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4e7b.4.A45.06monomerHHblitsX-ray2.00Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
5wi5.1.A42.21monomerHHblitsX-ray2.00Å0.410.99UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1
4eii.1.A44.82monomerHHblitsX-ray1.95Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
2rl2.1.A44.44homo-dimerBLASTX-ray2.30Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4e7g.1.A44.58monomerBLASTX-ray1.60Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
5u4h.1.A42.79homo-dimerBLASTX-ray1.05Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
1ryw.1.A44.82homo-tetramerHHblitsX-ray2.30Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
1dlg.3.C44.82homo-tetramerHHblitsX-ray1.90Å0.410.98UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYL TRANSFERASE MURA
1dlg.3.B44.82homo-tetramerHHblitsX-ray1.90Å0.410.98UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYL TRANSFERASE MURA
3v4t.1.A44.82homo-tetramerHHblitsX-ray2.50Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3v5v.1.A44.82homo-tetramerHHblitsX-ray2.70Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3v5v.1.D44.82homo-tetramerHHblitsX-ray2.70Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4e7f.1.A44.82monomerHHblitsX-ray2.15Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4e7f.2.A44.82monomerHHblitsX-ray2.15Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4e7e.2.A44.82monomerHHblitsX-ray2.30Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
5u4h.1.A42.55homo-dimerHHblitsX-ray1.05Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4e7g.1.A44.10monomerHHblitsX-ray1.60Å0.410.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
5ujs.1.A40.63homo-dimerBLASTX-ray2.46Å0.400.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
5ujs.1.B40.63homo-dimerBLASTX-ray2.46Å0.400.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
5ujs.1.A40.24homo-dimerHHblitsX-ray2.46Å0.400.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
5ujs.1.B40.24homo-dimerHHblitsX-ray2.46Å0.400.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
2yvw.1.A40.72monomerHHblitsX-ray1.81Å0.390.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
2yvw.1.A41.16monomerBLASTX-ray1.81Å0.400.98UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4fqd.1.A27.40homo-dimerHHblitsX-ray2.50Å0.330.98NikO protein
4fqd.1.A31.83homo-dimerBLASTX-ray2.50Å0.360.94NikO protein
3rmt.1.B23.63homo-tetramerBLASTX-ray2.80Å0.330.953-phosphoshikimate 1-carboxyvinyltransferase 1
3rmt.1.A23.63homo-tetramerBLASTX-ray2.80Å0.330.953-phosphoshikimate 1-carboxyvinyltransferase 1
3rmt.1.D23.63homo-tetramerBLASTX-ray2.80Å0.330.953-phosphoshikimate 1-carboxyvinyltransferase 1
4n3p.2.A22.60monomerHHblitsX-ray2.50Å0.310.96Serine Hydrolase OSH18
4n3p.1.A22.60monomerHHblitsX-ray2.50Å0.310.96Serine Hydrolase OSH18
3tr1.1.A20.68monomerHHblitsX-ray2.00Å0.300.973-phosphoshikimate 1-carboxyvinyltransferase
5buf.1.A20.34monomerHHblitsX-ray2.37Å0.300.963-phosphoshikimate 1-carboxyvinyltransferase
5buf.2.A20.34monomerHHblitsX-ray2.37Å0.300.963-phosphoshikimate 1-carboxyvinyltransferase
3rmt.1.B21.18homo-tetramerHHblitsX-ray2.80Å0.310.963-phosphoshikimate 1-carboxyvinyltransferase 1
3rmt.1.A21.18homo-tetramerHHblitsX-ray2.80Å0.310.963-phosphoshikimate 1-carboxyvinyltransferase 1
3rmt.1.D21.18homo-tetramerHHblitsX-ray2.80Å0.310.963-phosphoshikimate 1-carboxyvinyltransferase 1
5bs5.1.A19.80monomerHHblitsX-ray2.49Å0.300.973-phosphoshikimate 1-carboxyvinyltransferase
5bs5.2.A19.80monomerHHblitsX-ray2.49Å0.300.973-phosphoshikimate 1-carboxyvinyltransferase
4egr.1.A20.44monomerHHblitsX-ray2.50Å0.300.973-phosphoshikimate 1-carboxyvinyltransferase
3roi.1.A20.44monomerHHblitsX-ray2.20Å0.300.973-phosphoshikimate 1-carboxyvinyltransferase
3roi.2.A20.44monomerHHblitsX-ray2.20Å0.300.973-phosphoshikimate 1-carboxyvinyltransferase
4gfp.1.A20.44monomerHHblitsX-ray2.70Å0.300.973-phosphoshikimate 1-carboxyvinyltransferase
4n3p.2.A26.72monomerBLASTX-ray2.50Å0.330.93Serine Hydrolase OSH18
4n3p.1.A26.72monomerBLASTX-ray2.50Å0.330.93Serine Hydrolase OSH18
1rf4.1.A26.46monomerBLASTX-ray2.20Å0.330.935-enolpyruvylshikimate-3-phosphate synthase
1rf5.2.A26.46monomerBLASTX-ray2.30Å0.330.935-enolpyruvylshikimate-3-phosphate synthase
1rf5.3.A26.46monomerBLASTX-ray2.30Å0.330.935-enolpyruvylshikimate-3-phosphate synthase
1rf5.4.A26.46monomerBLASTX-ray2.30Å0.330.935-enolpyruvylshikimate-3-phosphate synthase
1rf5.1.A26.46monomerBLASTX-ray2.30Å0.330.935-enolpyruvylshikimate-3-phosphate synthase
2qfs.1.A21.34monomerHHblitsX-ray1.55Å0.310.953-phosphoshikimate 1-carboxyvinyltransferase
3fk1.1.A21.34monomerHHblitsX-ray1.70Å0.310.953-phosphoshikimate 1-carboxyvinyltransferase
2aay.1.A21.34monomerHHblitsX-ray1.55Å0.310.953-phosphoshikimate 1-carboxyvinyltransferase
2qfu.1.A21.34monomerHHblitsX-ray1.60Å0.310.953-phosphoshikimate 1-carboxyvinyltransferase
1mi4.1.A21.34monomerHHblitsX-ray1.70Å0.310.955-enolpyruvylshikimate-3-phosphate synthase
3fjz.1.A21.34monomerHHblitsX-ray1.70Å0.310.953-phosphoshikimate 1-carboxyvinyltransferase
2gg6.1.A19.85monomerHHblitsX-ray1.64Å0.300.963-phosphoshikimate 1-carboxyvinyltransferase
2gg4.1.A19.85monomerHHblitsX-ray2.10Å0.300.963-phosphoshikimate 1-carboxyvinyltransferase
2ggd.1.A19.85monomerHHblitsX-ray1.70Å0.300.963-phosphoshikimate 1-carboxyvinyltransferase
1q36.1.A21.09monomerHHblitsX-ray1.60Å0.310.953-phosphoshikimate 1-carboxyvinyltransferase
1rf4.1.A21.64monomerHHblitsX-ray2.20Å0.310.955-enolpyruvylshikimate-3-phosphate synthase
1rf5.2.A21.64monomerHHblitsX-ray2.30Å0.310.955-enolpyruvylshikimate-3-phosphate synthase
1rf5.3.A21.64monomerHHblitsX-ray2.30Å0.310.955-enolpyruvylshikimate-3-phosphate synthase
1rf5.4.A21.64monomerHHblitsX-ray2.30Å0.310.955-enolpyruvylshikimate-3-phosphate synthase
1rf5.1.A21.64monomerHHblitsX-ray2.30Å0.310.955-enolpyruvylshikimate-3-phosphate synthase
3nvs.1.A20.40monomerHHblitsX-ray1.02Å0.300.953-phosphoshikimate 1-carboxyvinyltransferase
2pqd.1.A20.00monomerHHblitsX-ray1.77Å0.300.963-phosphoshikimate 1-carboxyvinyltransferase
2pqb.1.A19.75monomerHHblitsX-ray1.80Å0.300.963-phosphoshikimate 1-carboxyvinyltransferase
5xwb.1.A19.11monomerHHblitsX-ray2.20Å0.300.953-phosphoshikimate 1-carboxyvinyltransferase
5xwb.2.A19.11monomerHHblitsX-ray2.20Å0.300.953-phosphoshikimate 1-carboxyvinyltransferase
2bjb.1.A17.04monomerHHblitsX-ray1.80Å0.290.943-PHOSPHOSHIKIMATE 1-CARBOXYVINYLTRANSFERASE
2o0x.1.A16.83monomerHHblitsX-ray1.96Å0.290.943-phosphoshikimate 1-carboxyvinyltransferase
2o15.1.A16.83monomerHHblitsX-ray1.95Å0.290.943-PHOSPHOSHIKIMATE 1-CARBOXYVINYLTRANSFERASE
3nvs.1.A18.79monomerHHblitsX-ray1.02Å0.290.783-phosphoshikimate 1-carboxyvinyltransferase
4gfp.1.A18.90monomerHHblitsX-ray2.70Å0.290.783-phosphoshikimate 1-carboxyvinyltransferase
5xwb.1.A17.59monomerHHblitsX-ray2.20Å0.290.773-phosphoshikimate 1-carboxyvinyltransferase
5xwb.2.A17.59monomerHHblitsX-ray2.20Å0.290.773-phosphoshikimate 1-carboxyvinyltransferase
5buf.1.A19.06monomerHHblitsX-ray2.37Å0.290.763-phosphoshikimate 1-carboxyvinyltransferase
5buf.2.A19.06monomerHHblitsX-ray2.37Å0.290.763-phosphoshikimate 1-carboxyvinyltransferase
5bs5.1.A19.44monomerHHblitsX-ray2.49Å0.300.753-phosphoshikimate 1-carboxyvinyltransferase
5bs5.2.A19.44monomerHHblitsX-ray2.49Å0.300.753-phosphoshikimate 1-carboxyvinyltransferase
2bjb.1.A19.06monomerHHblitsX-ray1.80Å0.290.763-PHOSPHOSHIKIMATE 1-CARBOXYVINYLTRANSFERASE
3r38.1.A17.54homo-dimerHHblitsX-ray2.23Å0.280.77UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1
2o0x.1.A19.18monomerHHblitsX-ray1.96Å0.290.753-phosphoshikimate 1-carboxyvinyltransferase
2o15.1.A19.18monomerHHblitsX-ray1.95Å0.290.753-PHOSPHOSHIKIMATE 1-CARBOXYVINYLTRANSFERASE
2qfu.1.A18.50monomerHHblitsX-ray1.60Å0.290.753-phosphoshikimate 1-carboxyvinyltransferase
1q36.1.A18.50monomerHHblitsX-ray1.60Å0.290.753-phosphoshikimate 1-carboxyvinyltransferase
3tr1.1.A18.87monomerHHblitsX-ray2.00Å0.290.753-phosphoshikimate 1-carboxyvinyltransferase
4egr.1.A18.87monomerHHblitsX-ray2.50Å0.290.753-phosphoshikimate 1-carboxyvinyltransferase
3roi.1.A18.87monomerHHblitsX-ray2.20Å0.290.753-phosphoshikimate 1-carboxyvinyltransferase
3roi.2.A18.87monomerHHblitsX-ray2.20Å0.290.753-phosphoshikimate 1-carboxyvinyltransferase
2qfs.1.A18.50monomerHHblitsX-ray1.55Å0.290.753-phosphoshikimate 1-carboxyvinyltransferase
2aay.1.A18.50monomerHHblitsX-ray1.55Å0.290.753-phosphoshikimate 1-carboxyvinyltransferase
3fk1.1.A18.50monomerHHblitsX-ray1.70Å0.290.753-phosphoshikimate 1-carboxyvinyltransferase
3fjz.1.A18.50monomerHHblitsX-ray1.70Å0.290.753-phosphoshikimate 1-carboxyvinyltransferase
1mi4.1.A18.24monomerHHblitsX-ray1.70Å0.290.755-enolpyruvylshikimate-3-phosphate synthase
3rmt.1.B20.38homo-tetramerHHblitsX-ray2.80Å0.300.743-phosphoshikimate 1-carboxyvinyltransferase 1
3rmt.1.A20.38homo-tetramerHHblitsX-ray2.80Å0.300.743-phosphoshikimate 1-carboxyvinyltransferase 1
3rmt.1.D20.38homo-tetramerHHblitsX-ray2.80Å0.300.743-phosphoshikimate 1-carboxyvinyltransferase 1
3sg1.1.A17.30monomerHHblitsX-ray2.60Å0.290.75UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1
5ujs.1.A17.30homo-dimerHHblitsX-ray2.46Å0.280.75UDP-N-acetylglucosamine 1-carboxyvinyltransferase
5ujs.1.B17.30homo-dimerHHblitsX-ray2.46Å0.280.75UDP-N-acetylglucosamine 1-carboxyvinyltransferase
2ggd.1.A18.55monomerHHblitsX-ray1.70Å0.280.753-phosphoshikimate 1-carboxyvinyltransferase
2pqd.1.A18.24monomerHHblitsX-ray1.77Å0.280.753-phosphoshikimate 1-carboxyvinyltransferase
4fqd.1.A14.51homo-dimerHHblitsX-ray2.50Å0.270.77NikO protein
2yvw.1.A15.26monomerHHblitsX-ray1.81Å0.270.76UDP-N-acetylglucosamine 1-carboxyvinyltransferase
5bq2.1.A16.40homo-tetramerHHblitsX-ray1.70Å0.270.74UDP-N-acetylglucosamine 1-carboxyvinyltransferase
5u4h.1.A14.02homo-dimerHHblitsX-ray1.05Å0.290.62UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4n3p.2.A20.62monomerHHblitsX-ray2.50Å0.310.61Serine Hydrolase OSH18
4n3p.1.A20.62monomerHHblitsX-ray2.50Å0.310.61Serine Hydrolase OSH18
2z2c.1.A18.46homo-tetramerHHblitsX-ray2.05Å0.300.61UDP-N-acetylglucosamine 1-carboxyvinyltransferase
1a2n.1.A18.46homo-trimerHHblitsX-ray2.80Å0.300.61UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYL TRANSFERASE
1rf4.1.A21.01monomerHHblitsX-ray2.20Å0.310.615-enolpyruvylshikimate-3-phosphate synthase
1rf5.2.A21.01monomerHHblitsX-ray2.30Å0.310.615-enolpyruvylshikimate-3-phosphate synthase
1rf5.3.A21.01monomerHHblitsX-ray2.30Å0.310.615-enolpyruvylshikimate-3-phosphate synthase
1rf5.4.A21.01monomerHHblitsX-ray2.30Å0.310.615-enolpyruvylshikimate-3-phosphate synthase
1rf5.1.A21.01monomerHHblitsX-ray2.30Å0.310.615-enolpyruvylshikimate-3-phosphate synthase
4r7u.1.A15.27homo-tetramerHHblitsX-ray2.45Å0.290.62UDP-N-acetylglucosamine 1-carboxyvinyltransferase
2gg6.1.A22.96monomerHHblitsX-ray1.64Å0.300.613-phosphoshikimate 1-carboxyvinyltransferase
2gg4.1.A22.96monomerHHblitsX-ray2.10Å0.300.613-phosphoshikimate 1-carboxyvinyltransferase
2pqb.1.A22.96monomerHHblitsX-ray1.80Å0.300.613-phosphoshikimate 1-carboxyvinyltransferase
5wi5.1.A16.92monomerHHblitsX-ray2.00Å0.290.61UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1
3zh3.1.A16.03monomerHHblitsX-ray2.90Å0.280.62UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE
3zh4.1.A16.09monomerHHblitsX-ray1.80Å0.280.62UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE
4e7g.1.A19.69monomerHHblitsX-ray1.60Å0.300.60UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3swd.1.A18.90monomerHHblitsX-ray2.50Å0.300.60UDP-N-acetylglucosamine 1-carboxyvinyltransferase
1naw.1.A19.69homo-tetramerHHblitsX-ray2.00Å0.300.60UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYL-TRANSFERASE
1naw.1.B19.69homo-tetramerHHblitsX-ray2.00Å0.300.60UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYL-TRANSFERASE
3spb.1.A19.29homo-tetramerHHblitsX-ray2.30Å0.300.60UDP-N-acetylglucosamine 1-carboxyvinyltransferase
1eyn.1.A19.29monomerHHblitsX-ray1.70Å0.300.60UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE
1ejc.1.A19.29monomerHHblitsX-ray1.80Å0.300.60UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYLTRANSFERASE
3su9.1.A19.29monomerHHblitsX-ray2.20Å0.300.60UDP-N-acetylglucosamine 1-carboxyvinyltransferase
1ybg.1.A19.29homo-tetramerHHblitsX-ray2.60Å0.300.60UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3spb.1.B19.29homo-tetramerHHblitsX-ray2.30Å0.300.60UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3kqa.1.A19.29monomerHHblitsX-ray2.25Å0.300.60UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3kqa.4.A19.29monomerHHblitsX-ray2.25Å0.300.60UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3lth.1.A19.29monomerHHblitsX-ray1.75Å0.300.60UDP-N-acetylglucosamine 1-carboxyvinyltransferase
1ejd.3.B19.29homo-tetramerHHblitsX-ray1.55Å0.300.60UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYLTRANSFERASE
4e7d.1.A19.29monomerHHblitsX-ray2.50Å0.300.60UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4e7d.4.A19.29monomerHHblitsX-ray2.50Å0.300.60UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4e7b.3.A19.29monomerHHblitsX-ray2.00Å0.300.60UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4e7b.2.A19.29monomerHHblitsX-ray2.00Å0.300.60UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4e7d.3.A19.29monomerHHblitsX-ray2.50Å0.300.60UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4e7b.4.A19.29monomerHHblitsX-ray2.00Å0.300.60UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3kr6.1.A18.50monomerHHblitsX-ray1.70Å0.300.60UDP-N-acetylglucosamine 1-carboxyvinyltransferase
1uae.1.A18.50homo-trimerHHblitsX-ray1.80Å0.300.60UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYL TRANSFERASE
1q3g.1.A18.90homo-tetramerHHblitsX-ray2.65Å0.300.60UDP-N-acetylglucosamine 1-carboxyvinyltransferase
1ryw.1.A18.90homo-tetramerHHblitsX-ray2.30Å0.300.60UDP-N-acetylglucosamine 1-carboxyvinyltransferase
1dlg.3.C18.90homo-tetramerHHblitsX-ray1.90Å0.300.60UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYL TRANSFERASE MURA
1dlg.3.B18.90homo-tetramerHHblitsX-ray1.90Å0.300.60UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYL TRANSFERASE MURA
3swa.1.A18.90monomerHHblitsX-ray1.90Å0.300.60UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4eii.1.A18.90monomerHHblitsX-ray1.95Å0.300.60UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3v4t.1.A18.97homo-tetramerHHblitsX-ray2.50Å0.300.60UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3v5v.1.A18.97homo-tetramerHHblitsX-ray2.70Å0.300.60UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3v5v.1.D18.97homo-tetramerHHblitsX-ray2.70Å0.300.60UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4e7f.1.A18.97monomerHHblitsX-ray2.15Å0.300.60UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4e7f.2.A18.97monomerHHblitsX-ray2.15Å0.300.60UDP-N-acetylglucosamine 1-carboxyvinyltransferase
4e7e.2.A18.97monomerHHblitsX-ray2.30Å0.300.60UDP-N-acetylglucosamine 1-carboxyvinyltransferase
2rl2.1.A16.93homo-dimerHHblitsX-ray2.30Å0.290.60UDP-N-acetylglucosamine 1-carboxyvinyltransferase
3vcy.1.A16.54monomerHHblitsX-ray1.93Å0.290.60UDP-N-acetylglucosamine 1-carboxyvinyltransferase
1rf4.1.A26.96monomerBLASTX-ray2.20Å0.350.545-enolpyruvylshikimate-3-phosphate synthase
1rf5.2.A26.96monomerBLASTX-ray2.30Å0.350.545-enolpyruvylshikimate-3-phosphate synthase
1rf5.3.A26.96monomerBLASTX-ray2.30Å0.350.545-enolpyruvylshikimate-3-phosphate synthase
1rf5.4.A26.96monomerBLASTX-ray2.30Å0.350.545-enolpyruvylshikimate-3-phosphate synthase
1rf5.1.A26.96monomerBLASTX-ray2.30Å0.350.545-enolpyruvylshikimate-3-phosphate synthase
3ti2.1.A17.59monomerHHblitsX-ray1.90Å0.290.513-phosphoshikimate 1-carboxyvinyltransferase
1p88.1.A19.12monomerHHblitsNMRNA0.290.483-phosphoshikimate 1-carboxyvinyltransferase
1p89.1.A19.12monomerHHblitsNMRNA0.290.483-phosphoshikimate 1-carboxyvinyltransferase
3ti2.1.A12.62monomerHHblitsX-ray1.90Å0.270.493-phosphoshikimate 1-carboxyvinyltransferase
1p88.1.A16.33monomerHHblitsNMRNA0.290.463-phosphoshikimate 1-carboxyvinyltransferase
1p89.1.A16.33monomerHHblitsNMRNA0.290.463-phosphoshikimate 1-carboxyvinyltransferase
4n3p.2.A31.50monomerBLASTX-ray2.50Å0.360.30Serine Hydrolase OSH18
4n3p.1.A31.50monomerBLASTX-ray2.50Å0.360.30Serine Hydrolase OSH18
5th5.1.A13.51homo-dimerHHblitsX-ray2.41Å0.270.097-carboxy-7-deazaguanine synthase
5tgs.1.A13.51homo-dimerHHblitsX-ray2.55Å0.270.097-carboxy-7-deazaguanine synthase