|
PFI-1
|
BRD4
|
Chromatin other
|
71271629
|
16
|
-3,363
|
347,394
|
0,8236
|
0
|
|
GSK690693
|
AKT1, AKT2, AKT3
|
PI3K/MTOR signaling
|
16725726
|
54
|
-3,299
|
425,491
|
1,8279
|
0
|
|
(5Z)-7-Oxozeaenol
|
TAK1
|
Other, kinases
|
9863776
|
99
|
-3,127
|
362,377
|
1,8679
|
0
|
|
Luminespib
|
HSP90
|
Protein stability and degradation
|
10096043
|
89
|
-3,108
|
465,548
|
1,3356
|
0
|
|
Parthenolide
|
HDAC1
|
Chromatin histone acetylation
|
7251185
|
103
|
-2,968
|
248,321
|
2,7525
|
0
|
|
AS605240
|
PI3Kgamma
|
PI3K/MTOR signaling
|
5289247
|
118
|
-2,955
|
257,273
|
0,927
|
0
|
|
Camptothecin
|
TOP1
|
DNA replication
|
104842
|
13
|
-2,948
|
392,41
|
1,5976
|
0
|
|
Phenformin
|
Biguanide agent
|
Other
|
8249
|
148
|
-2,89
|
205,264
|
0,2158
|
0
|
|
Enzastaurin
|
PKCB
|
Other, kinases
|
176167
|
135
|
-2,862
|
515,615
|
3,1099
|
1
|
|
PF-4708671
|
S6K1
|
PI3K/MTOR signaling
|
51371303
|
23
|
-2,841
|
390,412
|
2,7412
|
0
|
|
GW441756
|
NTRK1
|
RTK signaling
|
9943465
|
93
|
-2,786
|
275,31
|
1,491
|
0
|
|
CP466722
|
ATM
|
Genome integrity
|
44551660
|
31
|
-2,765
|
349,353
|
2,1837
|
0
|
|
NSC-207895
|
MDM4
|
p53 pathway
|
42640
|
145
|
-2,647
|
279,255
|
-0,4824
|
0
|
|
IOX2
|
EGLN1
|
Other
|
54685215
|
20
|
-2,61
|
352,345
|
0,5889
|
0
|
|
Elesclomol
|
HSP90
|
Protein stability and degradation
|
300471
|
131
|
-2,416
|
400,526
|
1,2946
|
0
|
|
Piperlongumine
|
Induces reactive oxygen species
|
Other
|
637858
|
125
|
-2,393
|
317,34
|
1,7755
|
0
|
|
PAC-1
|
Procaspase-3, Procaspase-7
|
Apoptosis regulation
|
6753378
|
108
|
-2,316
|
392,501
|
1,0309
|
0
|
|
PHA-793887
|
CDK2, CDK7, CDK5
|
Cell cycle
|
46191454
|
30
|
-2,237
|
361,488
|
1,3557
|
0
|
|
Lenalidomide
|
CRBN
|
Protein stability and degradation
|
216326
|
132
|
-2,085
|
259,264
|
-0,7383
|
0
|
|
5-Fluorouracil
|
Antimetabolite (DNA & RNA)
|
Other
|
3385
|
152
|
-1,765
|
130,078
|
-0,8399
|
0
|
